Synthesis and Pharmacological Evaluation of Newer Substituted 2-oxo/thiobarbiturinylbenzoxa/thiazepine Derivatives as Potent Anticonvulsant Agents
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چکیده
A new series of 4-(2'-Oxo/thiobarbiturinyl)-2-(substitutedphenyl)-3-[(substituted aminomethylene)]-2,3-dihydro-1,5-benzothiazepines (5a-5l) and 4-(2'-oxo/thiobarbiturinyl)-2(substituted-phenyl)-3-(substitutedaminomethylene)]-2,3-dihydro-1, 5benzoxazepines (6a-6l) were synthesized. All the newly synthesized compounds were screened in vivo, for their acute toxicity and anticonvulsant activity in MES and PTZ models and were compared with standard drugs phenytoin sodium and sodium valporate. Out of the compounds studied, the most active compound of this series was 5h, showed activity (90%) more potent than the standard drug.
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تاریخ انتشار 2015